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Search Results for " tnf β "

Targets Recommended: p38 MAPK TNF

39

抑制剂 & 化合物

8

天然产物

1

化合物库

32

重组蛋白

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Cat. No.	Product Name
L9840	抗阿尔茨海默症化合物库		986 compounds
	986 种阿尔茨海默症相关的化合物集合，可用于高通量和高内涵筛选；

化合物库

抗阿尔茨海默症化合物库

Cat.No: L9840

Compounds: 986

Cat. No.	Product Name	Target	Signaling Pathways
T12997	SR-318	p38 MAPK; TNF	Apoptosis; MAPK
	SR-318 是p38 MAPK 的选择性抑制剂，对 p38α，p38β 和 p38α/β 的IC50分别为 5 nM，32 nM 和 6.11 μM。它有效抑制全血中TNF-α的释放，IC50为 283 nM。它显示出抗癌和抗炎活性。
T8798	MSA-2	STING	Immunology/Inflammation
	MSA-2 是可口服的非核苷酸 STING 激动剂，以具有纳摩尔亲和力的非共价二聚体形式与 STING 结合。它在同基因小鼠肿瘤模型中显示抗肿瘤活性，与抗 PD-1 协同作用，可刺激肿瘤分泌干扰素-β，诱导肿瘤消退，具有持久的抗肿瘤免疫。
T83628	TNF/IFNγ-IN-1	Antioxidant; TNF; COX	Apoptosis; Immunology/Inflammation; Neuroscience; oxidation-reduction
	TNF/IFNγ-IN-1(TGA) 是 TNF 和 IFN-γ 的双重抑制剂。TNF/IFNγ-IN-1 具有潜在的抗氧化和抗炎活性，可用于类似阿尔茨海默等的神经退行性疾病。
T6150	TAK-715	p38 MAPK; Casein Kinase; JNK	MAPK; Metabolism; Stem Cells
	TAK-715 是一种具有口服活性的p38 MAPK 抑制剂，对 p38α 和 p38β 的IC50分别为 7.1 nM 和200 nM。它抑制酪蛋白激酶 I (CK1δ/ε)，调节 Wnt/β-catenin 信号传导的激活，有抗炎活性。
T77494	TNF-α-IN-9	TNF	Apoptosis
	TNF-α-IN-9 是一种 NDM-1 inhibitor-3类似物，是一种 TNF-α 抑制剂。TNF-α-IN-9 显示低抑制活性。
T19584L	TNF-α (31-45), human acetate TNF-α (31-45), human acetate(144796-71-4 free base)	Others	Others
	TNF-α (31-45), human acetate(144796-71-4 free base) 是一种肿瘤坏死因子-α 的肽。
T4403	AX-024 hydrochloride AX-024 HCl	IL Receptor; TNF; COX; IFNAR; Interleukin	Apoptosis; Immunology/Inflammation; Neuroscience
	AX-024 hydrochloride (AX-024 HCl) 是一种细胞因子释放抑制剂，可强烈抑制 IL-6、TNFα、IFN-γ、IL-10 和 IL-17A 的产生。它是口服可利用的 TCR-Nck 相互作用抑制剂，可选择性地抑制 TCR 触发的 T 细胞活化。它通过靶向 SH3结构域调节细胞信号传导，具有低毒、高效和高选择性的特点。
T40321	TNF-α-IN-6
	TNF-α-IN-6 is an orally efficacious allosteric inhibitor of TNFα ( K D = 6.8 nM).
T36127	TNF-α Antagonist
	TNF-α antagonist is an exocyclic peptide that mimics the critical TNF-α recognition loop on TNF receptor I complex and, thus, prevents ligand interaction with the receptor. By blocking the TNF receptor ligand contact site, this peptide interferes with both activating receptor activator of NF-κB (RANK) and TNF-α's recruitment and activation of osteoclasts. TNF-α antagonist has been used to block bone resorption in the study of systemic bone loss in rheumatoid arthritis and inflammatory bone destr...
T36097	TNF-α-IN-2
	TNF-α-IN-2 is a highly potent and orally bioavailable inhibitor of tumor necrosis factor alpha (TNFα), exhibiting an IC50 of 25 nM in the HTRF assay. It exerts its inhibitory effects by inducing conformational changes in the TNFα trimer upon binding, resulting in disrupted signaling when the trimer interacts with TNFR1. TNF-α-IN-2 holds promise as a valuable tool for investigating the pathogenesis of rheumatoid arthritis[1].
T79025	TNF-α-IN-10
	TNF-α-IN-10 (compound 8a) 作为IL-6与TNF-α的抑制剂，表现出抗炎活性。
T80973	TNF-α-IN-8
	TNF-α-IN-8 (compound I-42) 作为一种TNF-α抑制剂，属于异吲哚-亚胺类化合物，适用于肿瘤、心脏病、骨质疏松、炎症、过敏及自身免疫性疾病的研究。作为点击化学试剂，其Azide基团能与含Alkyne的分子配对，通过铜催化的叠氮－炔环加成反应(CuAAc)产生反应，也可与含DBCO或BCN基团的分子进行菌株促进的炔－叠氮环加成反应(SPAAC)。
T78730	TNF-α-IN-11
	TNF-α-IN-11 (Compound 10)是一种TNF-α抑制剂, KD值为12.06 μM。该化合物通过结合TNF-α并阻断其诱发的caspase和NF-κB信号通路激活，来实现其抑制作用。其具体机制包括抑制IκBα磷酸化和NF κB p65的核转位，适用于研究TNF-α介导的自身免疫性疾病。
T13175	TNF-α-IN-1	TNF	Apoptosis
	TNF-α-IN-1是 TNF-α 抑制剂。
T76026	TNF-α (31-45), human TFA
	TNF-α (31-45), human TFA 是人肿瘤坏死因子-α 的多肽片段。TNF α 是一种炎性细胞因子，可诱导坏死或凋亡。
T78272	Anti-Mouse TNF alpha Antibody (TN3-19.12)
	Anti-Mouse TNF alpha Antibody为Rat宿主源的IgG类针对小鼠TNF alpha的抗体抑制剂。
T78434	Mca-(endo-1a-Dap(Dnp))-TNF-Alpha (-5 to +6) amide (human) TFA
	Mca-(endo-1a-Dap(Dnp))-TNF-Alpha (-5 to +6) amide (human) TFA 为基于荧光共振能量转移的多肽底物，通过裂解引起的荧光强度变化来确定其活性。
T81838	Mca-(endo-1a-Dap(Dnp))-TNF-Alpha (-5 to +6) amide (human)
	Mca-(endo-1a-Dap(Dnp))-TNF-Alpha (-5 to +6) amide (human) 为一种基于FRET (荧光共振能量转移) 原理的多肽底物，通过其裂解引起的荧光强度变化来评估其活性。
T37445	Etanercept	TNF	Apoptosis
	Etanercept is a dimeric fusion protein that serves as a competitive TNF inhibitor by binding to TNF. It effectively inhibits the binding of both TNF-α and TNF-β to the TNF receptors on cell surfaces, thereby rendering TNF biologically inactive. Etanercept has demonstrated efficacy in treating rheumatoid arthritis, juvenile idiopathic arthritis, and plaque psoriasis.
T22021	ACHP IKK-2 Inhibitor VIII	IκB/IKK	NF-κB
	ACHP(IKK-2 Inhibitor VIII) 是一种新型具有选择性和高效性的 IKK 抑制剂，对IKK-α和IKK-β 具有抑制作用。ACHP 具有抗 HIV-1 活性，通过抑制 NF-κB 激活来抑制 HIV-1 长末端重复序列（LTR）驱动的基因表达，抑制 TNF-α 诱导的 NF-κB （p65）募集到 HIV-1 LTR。
T11886	LTβR-IN-1	Others; NF-κB; LTR	Immunology/Inflammation; NF-κB; Others
	LTβR-IN-1是一种有作用的、具有选择性的淋巴素β受体(LTβR)抑制剂。LTβR-IN-1 对TNF12A 的的 p52 的核易位抑制作用具有选择性，对 TNF-α 受体介导的 p65 的核易位无明显作用，却抑制受 TWEAK 或 Anti-LTβR 刺激的 p52 核易位，IC50为10 μM。LTβR-IN-1通过配体非依赖性方式实现对 NF-kB 信号通路的调节作用。
T8969	API-1 NSC177223	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	API-1 (NSC-177223) 是Akt/PKB 抑制剂，可同 PH 结构域相结合并抑制 Akt 膜易位，有效降低 Akt 的磷酸化水平。它可选择性的抑制PKB，对 PKC 和 PKA 的激活无抑制作用。它可以和 TNF 相关的凋亡诱导配体协同作用从而诱导细胞凋亡。
T69914	Variegatic acid
	Variegatic acid is a natural inhibitor of β-hexosaminidase release and tumor necrosis factor (TNF)-α secretion from rat basophilic leukemia (RBL 2H3) cells, with IC50 values of 10.4 μM and 16.8 μM, respectively, also inhibiting PKC β1 activity with an IC50 value of 36.2 μM.
T72614	STING modulator-3
	STINGmodulator-3 是一种 STING 抑制剂。在闪烁接近实验中，STINGmodulator-3 抑制 R232STING 的 Ki 值为 43.1 nM。STINGmodulator-3 对 THP-1 细胞的 IRF-3 激活和 TNF-β诱导无影响。
T63919	IKKβ-IN-1
	IKKβ-IN-1 是一种有效的、口服具有活力的 IkappaB(IKK-β) 抑制剂 (IC50: 0.20 μM)。IKKβ-IN-1 能够减少抑制小鼠巨噬细胞中 PGE2和 TNF-α的产生。IKKβ-IN-1 对小鼠具有保护作用，使其免受感染性休克诱导的死亡。
T75096	STING agonist-28
	STINGagonist-28 (CF510) 是一种非核苷酸小分子STING 激动剂。STINGagonist-23 激活STING，增加STING、TBK1和IRF3的磷酸化。STINGagonist-23 可促进肿瘤细胞中IFN-β、IL-6、CXCL-10、TNF-α、ISG-15和CCL-5的水平。STINGagonist-23 表现出抗SARS-CoV 系列的活性。
T75094	STING agonist-26
	STINGagonist-26 (CF508) 是一种非核苷酸小分子STING 激动剂。STINGagonist-23 激活STING，增加STING、TBK1和IRF3的磷酸化。STINGagonist-23 可促进肿瘤细胞中IFN-β、IL-6、CXCL-10、TNF-α、ISG-15和CCL-5的水平。STINGagonist-23 表现出抗SARS-CoV 系列的活性。
T75092	STING agonist-24
	STINGagonist-24 (CF504) 是一种非核苷酸小分子STING 激动剂。STINGagonist-23 激活STING，增加STING、TBK1和IRF3的磷酸化。STINGagonist-23 可促进肿瘤细胞中IFN-β、IL-6、CXCL-10、TNF-α、ISG-15和CCL-5的水平。STINGagonist-23 表现出抗SARS-CoV 系列的活性。
T75093	STING agonist-25
	STINGagonist-25 (CF505) 是一种非核苷酸小分子 STING 激动剂。STINGagonist-23 激活 STING，增加 STING、TBK1和 IRF3的磷酸化。STINGagonist-23 可促进肿瘤细胞中IFN-β、IL-6、CXCL-10、TNF-α、ISG-15和CCL-5的水平。STINGagonist-23 表现出抗SARS-CoV 系列的活性。
T63873	Anti-Aβ agent 1A
	Anti-Aβ agent 1A 是有效的抗淀粉样蛋白-β (amyloid-β) 剂。Anti-Aβ agent 1A 可明显抑制 LPS 诱导的 IL-1β、IL-6 和 TNF-α 水平，并能够利用线粒体途径减少 H2O2诱导的 SH-SY5Y 细胞凋亡，表现出抗氧化、抗炎、抗 Aβ 毒性和神经保护活性。Anti-Aβ agent 1A 能够用于研究阿尔兹海默症。
T75091	STING agonist-23
	STINGagonist-23 (CF502) 是一种非核苷酸小分子 STING 激动剂。STINGagonist-23 激活 STING，增加 STING、TBK1和 IRF3的磷酸化。STINGagonist-23 可促进肿瘤细胞中 IFN-β、IL-6、CXCL-10、TNF-α、ISG-15和 CCL-5的水平。STINGagonist-23 表现出抗 SARS-CoV 系列的活性。
T69898	NG25 trihydrochloride
	NG25 trihydrochloride is a type II kinase inhibitor that inhibits MAP4K2 and TAK1. It also inhibits the Src family kinases Src and LYN and Abl family kinases as well as CSK, FER, and p38α. NG 25 prevents TNF-α-induced IKKα/β phosphorylation and IκB-α degradation in L929 cells. It inhibits secretion of IFN-α and IFN-β induced by CpG type B and CL097, respectively. NG 25 decreases cell viability of HCT116KRASWT, and to a greater degree of HCT116KRASG13D, colorectal cancer cells in a concentration...
T71884	ß-Carboline-1-carboxylic acid
	β-Carboline-1-carboxylic acid is an alkaloid that has been found in P. quassioides and has diverse biological activities. It reduces LPS-induced increases in MCP-1, TNF-α, IL-6, and IL-1β levels in RAW 264.7 cells when used at a concentration of 15 µg/ml and inhibits the epithelial-to-mesenchymal transition (EMT) induced by TGF-β1 in A549 cells. β-Carboline-1-carboxylic acid induces cytotoxicity in CT26.WT, K562, and SGC-7901 cells (IC50s = 14.96, 22.11, and 19.7 µg/ml, respectively) but not Hep...
T37449	SR 12460
	SR 12460 is a mimetic of the IκB kinase β (IKKβ) NEMO/IKKγ-binding domain (NBD) that inhibits the protein-protein interaction between the IKK complex subunits NF-κB essential modulator (NEMO/IKKγ) and IKKβ.1It inhibits TNF-α-induced NF-κB activation in a reporter assay when used at concentrations ranging from 25 to 150 μM. It reduces LPS-induced production of IL-6 in RAW 264.7 cells. SR 12460 (30 mg/kg) improves grip strength in themdxmouse model of Duchenne muscular dystrophy. 1.Zhao, J., Zhang...
T36408	Rhein-13C4 Rhein-13C4
	Rhein-13C4 is intended for use as an internal standard for the quantification of rhein by GC- or LC-MS. Rhein is an anti-inflammatory anthraquinone found in rhubarb and is the bioactive derivative of its prodrug diacerein . At 10 μM, rhein inhibits IL-1β signaling, suppressing signaling through NF-κB, and reduces the expression of the matrix metalloproteases MMP-1 and MMP-13.1 It inhibits IKKβ (IC50 = 11.8 μM), decreasing iNOS and IL-6 expression in LPS-stimulated macrophages but paradoxically i...
T68321	AS1940477
	AS1940477 is p38 MAPK inhibitor. AS1940477 inhibited the enzymatic activity of recombinant p38α and β isoforms but showed no effect against other 100 protein kinases including p38γ and δ isoforms. In human peripheral blood mononuclear cells, AS1940477 inhibited lipopolysaccharide (LPS)- or phytohemagglutinin A (PHA)-induced production of proinflammatory cytokines, including TNFα, IL-1β, and IL-6 at low concentrations (LPS/TNFα, IC(50)=0.45n M; PHA/TNFα, IC(50)=0.40 nM). In addition, equivalent c...
T36779	NG 25 (hydrochloride hydrate)
	NG 25 is a type II kinase inhibitor that inhibits MAP4K2 and TAK1 (IC50s = 21.7 and 149 nM, respectively).1It also inhibits the Src family kinases Src and LYN (IC50s = 113 and 12.9 nM, respectively) and Abl family kinases (IC50s = 75.2 nM), as well as CSK, FER, and p38α (IC50s = 56.4, 82.3, and 102 nM, respectively). NG 25 (100 nM) prevents TNF-α-induced IKKα/β phosphorylation and IκB-α degradation in L929 cells. It inhibits secretion of IFN-α and IFN-β induced by CpG type B and CL097, respectiv...
T35864	T-5342126
	T-5342126 is a toll-like receptor 4 (TLR4) antagonist.1It reduces LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC50= 27.8 μM), as well as decreases LPS-induced IL-8, TNF-α, and IL-6 production in isolated human whole blood (IC50s = 110.5, 315.6, and 318.4 μM, respectively). T-5342126 (82 mg/kg) reduces ethanol intake and the abundance of ionized calcium-binding adapter molecule 1 (Iba1), a marker of microglial activation, in the central nucleus of the amygdala in ethanol-depen...
T35854	9(Z),11(E)-Conjugated Linoleic Acid (sodium salt)
	9(Z),11(E)-Conjugated linoleic acid is an isomer of linoleic acid that has been found in beef and milk fat.1It binds to peroxisome proliferator-activated receptor α (PPARα; IC50= 140 nM) and activates the receptor in a reporter assay using COS-1 cells expressing mouse PPARα when used at a concentration of 100 μM.29(Z),11(E)-Conjugated linoleic acid inhibits TNF-α-inducedGLUT4expression and increases insulin-stimulated glucose transport in 3T3-L1 adipocytes.3Dietary administration of 9(Z)11(E)-co...

化合物

Cat.No: T12997

Target: p38 MAPK, TNF

Cat.No: T8798

Target: STING

TNF/IFNγ-IN-1

Cat.No: T83628

Target: Antioxidant, TNF, COX

Cat.No: T6150

Target: p38 MAPK, Casein Kinase, JNK

Cat.No: T77494

Target: TNF

TNF-α (31-45), human acetate

Cat.No: T19584L

Synonym: TNF-α (31-45), human acetate(144796-71-4 free base)

Target: Others

AX-024 hydrochloride

Cat.No: T4403

Synonym: AX-024 HCl

Target: IL Receptor, TNF, COX, IFNAR, Interleukin

Cat.No: T40321

TNF-α Antagonist

Cat.No: T36127

Cat.No: T36097

Cat.No: T79025

Cat.No: T80973

Cat.No: T78730

Cat.No: T13175

Target: TNF

TNF-α (31-45), human TFA

Cat.No: T76026

Anti-Mouse TNF alpha Antibody (TN3-19.12)

Cat.No: T78272

Mca-(endo-1a-Dap(Dnp))-TNF-Alpha (-5 to +6) amide (human) TFA

Cat.No: T78434

Mca-(endo-1a-Dap(Dnp))-TNF-Alpha (-5 to +6) amide (human)

Cat.No: T81838

Cat.No: T37445

Target: TNF

Cat.No: T22021

Synonym: IKK-2 Inhibitor VIII

Target: IκB/IKK

Cat.No: T11886

Target: Others, NF-κB, LTR

Cat.No: T8969

Synonym: NSC177223

Target: Akt

Variegatic acid

Cat.No: T69914

STING modulator-3

Cat.No: T72614

Cat.No: T63919

STING agonist-28

Cat.No: T75096

STING agonist-26

Cat.No: T75094

STING agonist-24

Cat.No: T75092

STING agonist-25

Cat.No: T75093

Anti-Aβ agent 1A

Cat.No: T63873

STING agonist-23

Cat.No: T75091

NG25 trihydrochloride

Cat.No: T69898

ß-Carboline-1-carboxylic acid

Cat.No: T71884

Cat.No: T37449

Cat.No: T36408

Synonym: Rhein-13C4

Cat.No: T68321

NG 25 (hydrochloride hydrate)

Cat.No: T36779

Cat.No: T35864

9(Z),11(E)-Conjugated Linoleic Acid (sodium salt)

Cat.No: T35854

Cat. No.	Product Name	Target	Signaling Pathways
T6S2140	β-Anhydroicaritin Anhydroicaritin,Beta-Anhydroicaritin,脱水淫羊藿素	MMP; Others; TNF; Interleukin	Apoptosis; Immunology/Inflammation; Others; Proteases/Proteasome
	β-Anhydroicaritin 是从乳香提取的一种天然产物，具有重要的生物学和药理学作用，如抗骨质疏松症，雌激素调节和抗肿瘤特性。它改善牙周组织的降解，抑制糖尿病大鼠 TNF-α 和 MMP-3 的合成和分泌。它抑制细胞内 Ca2+的升高，并显著降低 iNOS 蛋白的表达。
T2P2870	Damascenone trans-damascenone,Beta-Damascenone,大马烯酮,大马酮	Others; NF-κB; Endogenous Metabolite	Metabolism; NF-κB; Others
	Damascenone (trans-damascenone) 是一种 E-和 Z-异构体大马士革酮的混合物，源于 Epipremnum pinnatum 的具有抗炎特性的特性化合物。
T3887	Rosarin	Others	Others
	Rosarin 是从玫瑰红景天中分离出来的肉桂醇糖苷。它抑制小鼠肾脏和大脑前额皮层中促炎因子 iNOS，IL-1β 和 TNF-α 的表达。它具有抗炎和神经保护作用。
TN6694	5,6-Benzoflavone β-Naphthoflavone,beta-NF	Antioxidant	oxidation-reduction
	5,6-Benzoflavone (β-Naphthoflavone) 是芳烃受体的外源配体，可破坏人肝癌 HepG2 细胞中的锌稳态。5,6-Benzoflavone (β-Naphthoflavone) 具有抗炎和抗氧化活性，抑制通过 AKT/Nrf-2/HO-1-NF-kappaB 信号转导轴，抑制 LPS 诱导的炎症，抑制TNF-α诱导的ICAM-1和VCAM-1表达，可用于研究神经退行性疾病。
T3240	Citronellol dihydrogeraniol,香茅醇,β-香茅醇,(±)-β-Citronellol	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Citronellol ((±)-β-Citronellol) 是一种单萜类化合物，从头状天竺葵中分离到。它可通过上调 TNF-α，RIP1/RIP3 的活性，下调 caspase-3/caspase-8 的活性，以及增加活性氧 (ROS) 的聚集来诱导肿瘤细胞的坏死性凋亡。
T6S0653	Linarin Buddleoflavonoloside,Buddleoside,Acacetin-7-O-rutinoside,Acaciin,Linarine,蒙花苷	TNF; AChE	Apoptosis; Neuroscience
	Linarin (Acacetin-7-O-rutinoside) 是一种选择性的乙酰胆碱酯酶 (AChE) 抑制剂，从薄荷花提取物中分离得到。
TN2461	Loganic acid 6′-O-β-D-glucoside 8-Epi-Loganic acid-6'-O-β-D-glucoside	Others	Others
	Loganic acid 6′-O-β-D-glucoside (8-Epi-Loganic acid-6'-O-β-D-glucoside) 是 Cistanche deserticola 的天然产物，可抑制 LPS 诱导的 NO 和 TNF-α 的产生。
T79977	Maceneolignan A
	Maceneolignan A，一种可从肉豆蔻（肉豆蔻科）假种皮分离的天然产品，有能力抑制RBL-2H3细胞内β-己糖胺酶释放，其IC50值为48.4 μM。同样，Maceneolignan A对抗原激活的RBL-2H3细胞中TNF-α释放的抑制作用，其IC50为63.7 μM。

天然产物

β-Anhydroicaritin

Cat.No: T6S2140

Synonym: Anhydroicaritin,Beta-Anhydroicaritin,脱水淫羊藿素

Target: MMP, Others, TNF, Interleukin

Cat.No: T2P2870

Synonym: trans-damascenone,Beta-Damascenone,大马烯酮,大马酮

Target: Others, NF-κB, Endogenous Metabolite

Cat.No: T3887

Target: Others

5,6-Benzoflavone

Cat.No: TN6694

Synonym: β-Naphthoflavone,beta-NF

Target: Antioxidant

Cat.No: T3240

Synonym: dihydrogeraniol,香茅醇,β-香茅醇,(±)-β-Citronellol

Target: Reactive Oxygen Species

Cat.No: T6S0653

Synonym: Buddleoflavonoloside,Buddleoside,Acacetin-7-O-rutinoside,Acaciin,Linarine,蒙花苷

Target: TNF, AChE

Loganic acid 6′-O-β-D-glucoside

Cat.No: TN2461

Synonym: 8-Epi-Loganic acid-6'-O-β-D-glucoside

Target: Others

Maceneolignan A

Cat.No: T79977

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Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02153	TNF beta Protein, Human, Recombinant LT,TNF β,TNFSF1,肿瘤坏死因子,TNF	Human	E. coli
	Lymphotoxin-alpha, also known as LT-alpha, TNF-beta, Tumor necrosis factor ligand superfamily member 1, LTA TNFSF1, and TNFB, is a secreted protein that belongs to the tumor necrosis factor family. TNF-beta/TNFSF1/Lymphotoxin alpha is highly inducible, secreted, and exists as a homotrimeric molecule. It is a cytokine that in its homotrimeric form binds to TNFRSF1A / TNFR1, TNFRSF1B / TNFBR, and TNFRSF14 / HVEM. In its heterotrimeric form with LTB, TNF-beta/TNFSF1/Lymphotoxin alpha binds to TNFRS...
TMPJ-00779	TNF alpha Protein, Rabbit, Recombinant TNF-a,Tumor Necrosis Factor,TNF-α,TNF<...	Rabbit	E. coli
	Tumor necrosis factor alpha (TNFα) is the prototypic ligand of the TNF superfamily. TNFα forms a homotrimer and functions by activating two types of receptors TNF-R1 (TNF receptor type 1,p55R) and TNF-R2 (TNF receptor type 2,p75R). TNFα is a pleiotropic cytokine that is capable to promote inflammation, to induce apoptotic cell death, and to inhibit tumorigenesis and viral replication. TNFα is a potent lymphoid factor that exerts cytotoxic effects on a wide range of tumor cells and certain other ...
TMPY-05039	LTBR Protein, Human, Recombinant (hFc) TNFR-RP,lymphotoxin β receptor (TNF	Human	HEK293 Cells
	LTBR Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 47.8 kDa and the accession number is P36941-1.
TMPY-01294	TNF alpha Protein, Mouse, Recombinant TNF-α,Tnfsf1a,TNF-alpha,TNF	Mouse	E. coli
	TNF alpha Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.39 kDa and the accession number is P06804.
TMPY-02202	TNF alpha Protein, Rat, Recombinant tumor necrosis factor,肿瘤坏死因子,TNF-α	Rat	E. coli
	TNF alpha Protein, Rat, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.4 kDa and the accession number is P16599.
TMPY-00936	TNF alpha Protein, Human, Recombinant TNFA,TNFSF2,TNF-alpha,TNF	Human	E. coli
	TNF alpha Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.5 kDa and the accession number is P01375.
TMPY-04146	TNF alpha Protein, Human, Recombinant (hFc) DIF,TNFA,tumor necrosis factor,TNFSF2,...	Human	HEK293 Cells
	TNF alpha Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.8 kDa and the accession number is P01375.
TMPY-00248	Lymphotoxin Beta Protein, Cynomolgus, Recombinant (His) Lymphotoxin β,lymphotoxin β (TNF ...	Cynomolgus	Baculovirus Insect Cells
	LTB (Lymphotoxin Beta) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. Heat-labile enterotoxin B subunit (LTB) of enterotoxigenic Escherichia coli (ETEC) is both a strong mucosal adjuvant and immunogen. It is a subunit vaccine candidate to be used against ETEC-induced diarrhea. It has already been expressed in seve...
TMPY-02069	TNF alpha Protein, Cynomolgus, Rhesus, Recombinant 肿瘤坏死因子,TNF-α,tumor necrosis factor	Cynomolgus,Rhesus	E. coli
	TNF alpha Protein, Cynomolgus, Rhesus, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.4 kDa and the accession number is NP_001040614.1.
TMPJ-00288	TNF RII Protein, Human, Recombinant (mFc) Tumor necrosis factor receptor 2,TNFRSF1B,p75,T...	Human	HEK293 Cells
	TNF RII Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag. The predicted molecular weight is 60 KDa and the accession number is P20333.
TMPH-02770	TNF beta Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo. TNF beta Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 23.8 kDa and the accession number is P09225.
TMPY-05516	TNF alpha Protein, Cynomolgus, Recombinant, Biotinylated 肿瘤坏死因子,tumor necrosis factor,TNF-α	Cynomolgus	E. coli
	TNF alpha Protein, Cynomolgus, Recombinant, Biotinylated is expressed in E. coli expression system. The predicted molecular weight is 17.4 kDa and the accession number is P79337.
TMPK-00583	TNF alpha Protein, Ferret, Recombinant (His) TNF-α,DIF,TNFα,TNF-alpha,TNF<...	Ferret	E. coli
	TNF alpha Protein, Ferret, Recombinant (His) is expressed in E. coli expression system with C-His tag. The predicted molecular weight is 18.88 kDa and the accession number is A3FBF1.
TMPJ-00280	TNF R1 Protein, Mouse, Recombinant Tnfrsf1a,Tumor necrosis factor receptor superfamily...	Mouse	E. coli
	Tumor necrosis factor receptor superfamily member 1A (Tnfrsf1a) is a member of the tumor necrosis factor receptor superfamily. Tnfrsf1a is one of the major receptors for the tumor necrosis factor-alpha. It can activate the transcription factor NF-κB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the...
TMPH-03745	TNF-alpha Protein, Zebrafish, Recombinant (His)	Danio rerio (Zebrafish)	E. coli
	TNF-alpha Protein, Zebrafish, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 23.6 kDa and the accession number is Q08CQ3.
TMPY-01594	TNF alpha Protein, Canine, Recombinant 肿瘤坏死因子,TNF-α,tumor necrosis factor	Canine	E. coli
	TNF alpha Protein, Canine, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.3 kDa and the accession number is A9LMQ0.
TMPY-02226	TNF alpha Protein, Ferret, Recombinant tumor necrosis factor,肿瘤坏死因子,TNF-α	Ferret	E. coli
	TNF alpha Protein, Ferret, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.3 kDa and the accession number is A3FBF1.
TMPK-00119	TNF alpha Protein, Cynomolgus, Recombinant (His) TNF α,TNFα,APC1 protein,TNF-alpha...	Cynomolgus	HEK293 Cells
	TNF alpha Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular weight is 18.35 kDa and the accession number is P79337.
TMPY-05237	TNF alpha Protein, Human, Recombinant, Biotinylated TNFSF2,DIF,TNF-α,tumor necrosis factor,肿瘤坏...	Human	E. coli
	TNF alpha Protein, Human, Recombinant, Biotinylated is expressed in E. coli expression system. The predicted molecular weight is 17.5 kDa and the accession number is P01375.
TMPJ-00287	TNF RII Protein, Human, Recombinant (hFc) TNF-R2,Tumor necrosis factor receptor superfamily m...	Human	HEK293 Cells
	TNF RII Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 60-90 KDa and the accession number is P20333.
TMPJ-00619	TNF RII Protein, Rhesus macaque, Recombinant (His) Tumor necrosis factor receptor superfamily member 1b,Tnf...	Rhesus	HEK293 Cells
	TNF RII Protein, Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 35-45 KDa and the accession number is F7EAF8.
TMPK-00120	TNF alpha Protein, Human, Recombinant (His & Avi) TNFα,APC1 protein,肿瘤坏死因子,TNFSF2,TNF	Human	HEK293 Cells
	TNF alpha Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 20.3 kDa and the accession number is P01375.
TMPH-01620	TNF beta Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.
TMPY-05187	TNF alpha Protein, Mouse, Recombinant, Biotinylated Tnfa,TNFSF2,肿瘤坏死因子,Tnfsf1a,TN...	Mouse	E. coli
	TNF alpha Protein, Mouse, Recombinant, Biotinylated is expressed in E. coli expression system. The predicted molecular weight is 17.4 kDa and the accession number is P06804.
TMPK-00121	TNF alpha Protein, Human, Recombinant (His & Avi), Biotinylated TNF,TNF-alpha,TNFATNF,DI...	Human	HEK293 Cells
	TNF alpha Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 20.3 kDa and the accession number is P01375.
TMPJ-00618	TNF RII Protein, Rhesus macaque, Recombinant (hFc) Tnfrsf1b,Tumor necrosis factor receptor superfamily...	Rhesus	HEK293 Cells
	TNF RII Protein, Rhesus macaque, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 60-80 KDa and the accession number is F7EAF8.
TMPJ-00124	TNF alpha Protein, Human, Recombinant (aa 77-233, His) TNF-a,TNF-α,Tumor Necrosis Factor,TNF<...	Human	E. coli
	TNF alpha Protein, Human, Recombinant (aa 77-233, His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 16 KDa and the accession number is P01375.
TMPJ-00274	LTBR Protein, Human, Recombinant (His) TNFCR,Tumor Necrosis Factor Receptor Superfamily Me...	Human	HEK293 Cells
	Tumor necrosis factor receptor superfamily member 3, also known as Lymphotoxin-beta receptor,Tumor necrosis factor C receptor,Tumor necrosis factor receptor 2-related protein,Tumor necrosis factor receptor type III,LTBR,TNFCR, TNFR3 and TNFRSF3, is a member of the tumor necrosis factor (TNF) family of receptors. LTBR is a single-pass type I membrane protein and contains four TNFR-Cys repeats. It is expressed on the surface of most cell types, but not on T and B lymphocytes. LTBR and its ligand p...
TMPJ-00296	TNF RII Protein, Mouse, Recombinant (His & Avi), Biotinylated Tumor necrosis factor receptor superfamily member 1b,Tnf...	Mouse	HEK293 Cells
	TNF RII Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-6xHis-Avi tag. The predicted molecular weight is 35-50 KDa and the accession number is Q545P4.
TMPJ-00125	TNF alpha Protein, Human, Recombinant (aa 57-233, His) TNFA,TNF-α,Cachectin,肿瘤坏死因子,TNF-A...	Human	E. coli
	TNF alpha Protein, Human, Recombinant (aa 57-233, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 18 KDa and the accession number is P01375.
TMPJ-00680	ANGPTL7 Protein, Human, Recombinant (His) CDT6,Cornea-derived transcript 6 protein,Angiopoietin-like p...	Human	HEK293 Cells
	Angiopoietin-like 7 (ANGPTL7) is a secreted glycoprotein that is structurally related to the angiopoietins. Members of this protein family contain an N-terminal coiled coil domain and a C-terminal fibrinogen-like domain. ANGPTL7 shares 89% aa sequence identity with mouse and rat ANGPTL7. It is secreted as a 45-50kDa monomer that forms disulfide-linked homotrimers and tetramers via the coiled coil domain. ANGPTL7 is expressed in the corneal stroma, trabecular meshwork, and sclera and is elevated ...
TMPY-03861	Amelotin Protein, Human, Recombinant (mFc) amelotin,UNQ689	Human	HEK293 Cells
	Amelotin (AMTN) is a tooth enamel protein which is expressed in maturation-stage ameloblasts and also in the internal basal lamina of junctional epithelium, a unique epithelial structure attached to the tooth surface which protects against the constant microbiological challenge to the periodontium. TNF-α stimulates AMTN gene transcription in human gingival epithelial cells via C/EBP1, C/EBP2, and YY1 elements in the human AMTN gene promoter.AMTN mRNA levels increased at 6 h and reached maximum a...

重组蛋白

TNF beta Protein, Human, Recombinant

Cat.No: TMPY-02153

Species: Human

Expression System: E. coli

TNF alpha Protein, Rabbit, Recombinant

Cat.No: TMPJ-00779

Species: Rabbit

Expression System: E. coli

LTBR Protein, Human, Recombinant (hFc)

Cat.No: TMPY-05039

Species: Human

Expression System: HEK293 Cells

TNF alpha Protein, Mouse, Recombinant

Cat.No: TMPY-01294

Species: Mouse

Expression System: E. coli

TNF alpha Protein, Rat, Recombinant

Cat.No: TMPY-02202

Species: Rat

Expression System: E. coli

TNF alpha Protein, Human, Recombinant

Cat.No: TMPY-00936

Species: Human

Expression System: E. coli

TNF alpha Protein, Human, Recombinant (hFc)

Cat.No: TMPY-04146

Species: Human

Expression System: HEK293 Cells

Lymphotoxin Beta Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPY-00248

Species: Cynomolgus

Expression System: Baculovirus Insect Cells

TNF alpha Protein, Cynomolgus, Rhesus, Recombinant

Cat.No: TMPY-02069

Species: Cynomolgus,Rhesus

Expression System: E. coli

TNF RII Protein, Human, Recombinant (mFc)

Cat.No: TMPJ-00288

Species: Human

Expression System: HEK293 Cells

TNF beta Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02770

Species: Mouse

Expression System: E. coli

TNF alpha Protein, Cynomolgus, Recombinant, Biotinylated

Cat.No: TMPY-05516

Species: Cynomolgus

Expression System: E. coli

TNF alpha Protein, Ferret, Recombinant (His)

Cat.No: TMPK-00583

Species: Ferret

Expression System: E. coli

TNF R1 Protein, Mouse, Recombinant

Cat.No: TMPJ-00280

Species: Mouse

Expression System: E. coli

TNF-alpha Protein, Zebrafish, Recombinant (His)

Cat.No: TMPH-03745

Species: Danio rerio (Zebrafish)

Expression System: E. coli

TNF alpha Protein, Canine, Recombinant

Cat.No: TMPY-01594

Species: Canine

Expression System: E. coli

TNF alpha Protein, Ferret, Recombinant

Cat.No: TMPY-02226

Species: Ferret

Expression System: E. coli

TNF alpha Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00119

Species: Cynomolgus

Expression System: HEK293 Cells

TNF alpha Protein, Human, Recombinant, Biotinylated

Cat.No: TMPY-05237

Species: Human

Expression System: E. coli

TNF RII Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00287

Species: Human

Expression System: HEK293 Cells

TNF RII Protein, Rhesus macaque, Recombinant (His)

Cat.No: TMPJ-00619

Species: Rhesus

Expression System: HEK293 Cells

TNF alpha Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00120

Species: Human

Expression System: HEK293 Cells

TNF beta Protein, Human, Recombinant (His)

Cat.No: TMPH-01620

Species: Human

Expression System: HEK293 Cells

TNF alpha Protein, Mouse, Recombinant, Biotinylated

Cat.No: TMPY-05187

Species: Mouse

Expression System: E. coli

TNF alpha Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00121

Species: Human

Expression System: HEK293 Cells

TNF RII Protein, Rhesus macaque, Recombinant (hFc)

Cat.No: TMPJ-00618

Species: Rhesus

Expression System: HEK293 Cells

TNF alpha Protein, Human, Recombinant (aa 77-233, His)

Cat.No: TMPJ-00124

Species: Human

Expression System: E. coli

LTBR Protein, Human, Recombinant (His)

Cat.No: TMPJ-00274

Species: Human

Expression System: HEK293 Cells

TNF RII Protein, Mouse, Recombinant (His & Avi), Biotinylated

Cat.No: TMPJ-00296

Species: Mouse

Expression System: HEK293 Cells

TNF alpha Protein, Human, Recombinant (aa 57-233, His)

Cat.No: TMPJ-00125

Species: Human

Expression System: E. coli

ANGPTL7 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00680

Species: Human

Expression System: HEK293 Cells

Amelotin Protein, Human, Recombinant (mFc)

Cat.No: TMPY-03861

Species: Human

Expression System: HEK293 Cells

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